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Solmedx Clinical Studies

As we develop data on our clinical studies, we would be happy to share our results with you. If you would like to receive new data as it is generated, please Contact Us and give us your email address. We promise to send only data and no promotional material.

Current ongoing clinical study:

Rutgers IRB Protocol No: 2011001111
Title: ROX analysis to create norms for patients suffering from pain associated with chronic disease. Principal Investigator: John Bach, MD, Rutgers NJMS, Department of Physical Medicine and Rehabilitation
Co-investigators: Zamir Brelvi, MD, PhD, Michael Demyen, MD, Rutgers New Jersey Medical School, Gastroenterology and Hepatology; Samyadev Datta, MD, Center for Pain Management; Andrew Kaufman, MD, Rutgers Comprehensive Pain Center
Study Coordinator: Sam Sofer, PhD, PE, Solmedx
Study Performance Sites: Apollo Medical Center, Parsippany, NJ; Center for Pain Management, Hackensack, NJ; Immedicenters, Bloomfield, Clifton, and Totowa, NJ; Rutgers University Hospital, Newark, NJ

We are currently seeking volunteers and patients for our clinical study on the relationship of pain and ROX levels. We need volunteers with essentially no pain (0-2 on a scale of 0 to 10); volunteers with pain that is largely controlled with medication (3-6 on a scale of 0 to 10); and volunteers with pain that largely cannot be controlled with medication (7-10 on a scale of 0 to 10). You may also volunteer if you have a chronic disease, such as diabetes, neuromuscular disease, asthma, cardiovascular disease, COPD, schizophrenia, bi-polar disease, etc.

The purpose of this multi-center study is to create norms for people suffering from pain associated with chronic disease. If you are interested in volunteering for this study:

(1) Please read the Study Abstract below;

(2) Please download and read the Consent to Take Part in a Research Study;

(3) Once you have read and understood the Abstract and Consent form, please call Dr. Sam Sofer, Project Coordinator, at 201-953-1719 with any questions you may have regarding the study and/or to discuss your participation in the study.

(4) You must then follow up with an appointment at one of the following participating clinics:

Dr. John Bach
Doctors Office Center
90 Bergen St.
Newark, NJ

Dr. Zamir Brelvi
Apollo Medical Center
148 Parsippany Rd.
Parsippany, NJ

Dr. Samyadev Datta; Monique Sweeney
Center for Pain Management
294 State St., Suite 1
Hackensack, NJ

Dr. Michael Demyen; Dr. Zamir Brelvi
Rutgers Doctors Office Center
90 Bergen St., Suite 2100
Newark, NJ

Dr. Andrew Kaufman
Rutgers Comprehensive Pain Center
90 Bergen St., Suite 3400
Newark, NJ

Dr. Zamir Brelvi
557 Broad St., Bloomfield, NJ
1355 Broad St., Clifton, NJ
500 Union Blvd., Totowa, NJ

(5) The Consent form and a Study Questionnaire must be signed and completed by a participating member of the study team above. Downloadable Questionnaire

(6) Please note that the Questionnaire is confidential and does not include any identification information, such as name, address, or social security number.

Abstract of Current Study:

The ROX™ Analyzer is a new tool, which is of potential use to quantify pain levels in individuals. Pain is very difficult to quantify, and a major obstacle in the treatment of pain is its subjective nature. No tools generating hard data have been available for aiding physicians to monitor the progress of treatments for pain1,2. We propose to use a ROX Analyzer to create norms for subjects with no reported pain, chronic treated pain, and treated but unstable pain. ROX Analyzers allow us to measure the viability of the oxygen delivery and concentration system, and are therefore of obvious importance in immune oxidative attack, oxidative liver detoxification, and mitochondrial energy generation. Our hypothesis is that the firing of nerves and generation of impulses also critically require an adequate and balanced oxygen delivery system. Thus, ROX analysis may be very useful in quantifying pain.

Abstract of Final Report of Completed Clinical Study

When blood is subjected to a protocol of increasing stress, hidden reservoirs of oxygen (O2) and nitric oxide (NO) are revealed. As stress applied to a blood sample increases, at first O2 vanishes suddenly and later re-appears, also suddenly. NO appears the same way, indicating a reservoir mechanism, into and from which these molecules are rapidly transported.

O2 and NO are key molecules involved in immune system function, and their transport characteristics in blood are key to the investigation and monitoring of any disease. The purpose of this paper is to present an immunography technique, which exploits blood stress profiles and is useful for evaluating disease level and progress in any patient.

Immunography is the use of an Immunogram Analyzer (IA) to generate blood stress profiles, called immunograms, to measure O2 and NO profiles. In this paper we demonstrate how to use immunography to evaluate Hepatitis C (Hep C) patients. On the basis of four known Hep C patient samples and 19 controls, we have found higher NO levels, along with higher oxidative activity, in the Hep C samples. Information about blood reservoirs of oxygen (ROX) and cellular boosting of oxygen (BOX) is also presented and discussed.

Planned Clinical Studies

Additional clinical studies are planned for ALS; Alzheimer’s, Huntington’s, MS, and other neurodegenerative diseases; Cancer; Complex Regional Pain Syndrome; Diabetes; HIV/AIDs; Parkinson’s Disease; and Rheumatoid Arthritis and other auto-immune diseases.

If you are interested in taking part in a clinical study, please Contact Us.

Exciting New Developments:

Rutgers Logo
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A Rutgers multi-center clinical study on Pain and ROX levels is currently underway. At present we are seeking volunteers and patients for our clinical study on the relationship of pain and ROX levels. The purpose of this Rutgers multi-center study is to create norms for patients suffering from pain associated with chronic disease. If you would like more information or are interested in volunteering for this study, click here.
Planned future clinical studies are based on the following hypotheses:
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ALS: Imbalanced ROX at the motor neuron leads to oxidative damage to the motor neuron and surrounding tissue.
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Alzheimer’s, Huntington’s, MS, and other neurodegenerative diseases: Imbalanced ROX, for nervous system operation and signaling, leads to oxidative damage of nerve tissue and surrounding tissue.
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Cancer: A tumor cannot be contained if there is insufficient ROX. A cancer patient with sufficient ROX can prevent a tumor from spreading by destroying any metastasized cancer cells.
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Complex Regional Pain Syndrome (CRPS): Out of balance ROX allows free radicals to send unexplained pain signals to the brain.
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Diabetes: If not enough ROX is delivered for glucose to be converted to energy, more insulin will be required to control a person’s sugar level.
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HIV/AIDs: When a T-cell recognizes a virus, it recruits a critical mass of ROX to destroy the virus. Insufficient ROX leads to the premature release of oxygen, destroying T-cells and surrounding tissues.
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Parkinson’s Disease: Only about 30% of people with the gene for Parkinson’s Disease (PD) actually get the disease. If less than a critical mass of ROX exists, radicals will be released in the brain and the surrounding tissues, resulting in widespread damage and causing a chain of events that leads to PD.
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Rheumatoid Arthritis (RA) and other auto-immune diseases: Insufficient ROX allows for the indiscriminate spread of radical oxygen species, thus damaging surrounding tissues.
©2014 SOLMEDX, LLC. All Rights Reserved P.O. Box 627, Nutley, NJ 07110 | Contact Us

Solmedx can be found online under the following tags:
interferon treatment, patient blood samples, ROX (reservoir oxygen capacity), Cancer, innate immune viability, AIDs, BOX, blood cell oxygen capacity,
adaptive immune system strength,
proper medication dosage, clinical studies,Hepatitis C, Diabetes, patient injury and drug toxicity Alzheimer's, ALS, and other neurodegenerative diseases; Cancer; Diabetes; HIV/AIDS, Huntington's Disease, Parkinson's Disease (PD), Rheumatoid Arthritis (RA) and other auto-immune diseases; and Complex Regional Pain Syndrome (CRPS)]

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